Molecular Activation by Peroxidases
نویسندگان
چکیده
منابع مشابه
Oxidative activation of benzidine and its derivatives by peroxidases.
Benzidine (4,4'-diaminobiphenyl) is a known human carcinogen; exposure to this substance resulted in an epidemic of bladder cancer among workers in the dye industry in Europe and North America. The chemical or enzymatic oxidation of benzidine proceeds via a racial cation detectable by electron spin resonance. Peroxidase-catalyzed oxidation of benzidine generates reactive electrophiles which rea...
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A molecular analysis of class III peroxidases from cotton (Gossypium hirsutum L.) was undertaken using the sequence of 12 genes available in databanks. Sequence comparison, phylogenetical analysis, and investigation of expression in organs were performed to characterize this group of peroxidases in cotton. All 12 genes possess the characteristics of class III peroxidases, including three conser...
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In 2008 melamine-contaminated infant formula and dairy products in China led to over 50,000 hospitalizations of children due to renal injuries. In North America during 2007 and in Asia during 2004, melamine-contaminated pet food products resulted in numerous pet deaths due to renal failure. Animal studies have confirmed the potent renal toxicity of melamine combined with cyanuric acid. We showe...
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Aristolochic acid I (AAI) and aristolochic acid II (AAII), the two major components of the carcinogenic plant extract aristolochic acid (AA), are known to be mutagenic and to form DNA adducts in vivo. According to the structures of the major DNA adducts identified in animals and humans, nitroreduction is the crucial pathway in the metabolic activation of these naturally occurring nitroarenes to...
متن کاملActivation energies by molecular dynamics with constraints
Recently Tobias and Broods introduced a method to compute by molecular dynamics with constraints the probability density P(r) = (&r-7)) associated with rate values i of a spatial coordinate r. In this Letter we extend their approach to the case of a general reaction coordinate C(r), an arbitrary function of the configuration-space coordinates. The generalized version is shown to be the integral...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2011
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2010.12.1418